Full Title:Physiology & Pharmacology
Language of Instruction:English
Module Code:PHAR S7022
 
Credits: 5
Valid From:Semester 1 - 2013/14 ( September 2013 )
Module Delivered in 1 programme(s)
Module Description:The aims of this module are; • To provide an overview of the physiological control of selected body systems. • To examine how these body systems are affected by drugs. • To show how drug activity depends upon the route of administration, absorption, distribution, metabolism and elimination of the drug. The aims of this module are; • To provide an overview of the physiological control of selected body systems. • To examine how these body systems are affected by drugs.
Learning Outcomes:
On successful completion of this module the learner should be able to
  1. Summarise the fundamental principles of pharmacodynamics and pharmacokinetics, explaining how plasma drug concentration is affected by the processes of absorption, distribution, metabolism and excretion.
  2. Construct concentration-response curves and interpret concentration-response data of selected agonists and antagonists through a combination of in-vitro and in-silico experimentation.
  3. Describe the cellular basis of drug action.
  4. Examine the process of autonomic neurotransmission and drugs which affect it.
  5. Discuss the physiology of selected body systems and how these are affected by clinically relevant drugs.
 

Module Content & Assessment

Indicative Content
• Physiological control
A review of cellular physiology and signalling mechanisms: intracellular Ca2+, ion channels and action potentials. The autonomic nervous system: structure and function, parasympathetic nervous system, sympathetic nervous system. Cholinergic neurotransmission: synthesis, storage, release and effect of acetylcholine at autonomic synapses, parasympathetic junctions and the neuromuscular junction. Adrenergic neurotransmission: synthesis, storage, release and actions of noradrenaline at sympathetic junctions.
• Basic pharmacological principles
Targets of drug action: ion channels, receptors, transporters and enzymes. Receptor pharmacology: agonists & antagonists, affinity vs efficacy and concentration-response curves. Receptor superfamilies and signal transduction mechanisms. Pharmacokinetics: the routes of administration, absorption, distribution, metabolism and elimination of drugs. The effects of lipid solubility, ionisation and pH partition upon drug accumulation
• Drugs and the body
An overview of the physiology and pharmacology of the renal system, cardiovascular system and nervous system. Lectures will include an examination of how clinically relevant drugs interact with each system.
Practical work:
Practical classes will include a combination of lab-based experiments and computer-simulations of classical pharmacology experiments. Computer based simulations of the effects of agonists and antagonists acting upon the isolated guinea pig ileum will be provided. These practicals provide an insight into the regulation of contractility of the gastrointestinal tract and the generation of concentration-response curves in the presence of reversible and non-reversible antagonists. Computer based simulations will also be used to assess the effects of different routes of administration, changing rates of absorption, altering patterns of drugs distribution and altering elimination rate constants upon the time course of plasma drug concentration. More traditional, laboratory based practicals will utilize isometric tension recordings and permit students to gain hands on experience working with live tissues and performing pharmacological experiments. These practical’s investigate the effect of autonomic receptor agonists on spontaneous contractile activity of smooth muscle and investigate how these are affected by a range of ion channel modulators and selective receptor antagonists.
Assessment Breakdown%
Course Work10.00%
Practical40.00%
End of Module Formal Examination50.00%

Full Time

Course Work
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Presentation Students will be assigned to groups of four and will deliver an oral presentation describing clinical conditions that affect the body and the pharmacological basis of their therapeutic treatment. 1,3,5 10.00 0 0 Sem 2 End 0
No Project
Practical
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Practical/Skills Evaluation Students will complete a range of practical classes, including computer based simulation experiments, in-vitro isometric tension recordings and blood pressure monitoring from human volunteers. Students will be supplied with a practical manual with details of each experimental procedure. Marks will be awarded for successful completion of the manual. 1,2,3,4 40.00 0 0 n/a 0
End of Module Formal Examination
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Formal Exam End-of-Semester Final Examination 1,2,3,4,5 50.00 0 0 End-of-Semester 0
Reassessment Requirement
A repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.

DKIT reserves the right to alter the nature and timings of assessment

 

Module Workload & Resources

Workload: Full Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture No Description 2.00 Every Week 2.00
Practical No Description 2.00 Every Week 2.00
Tutorial No Description 1.00 Every Week 1.00
Independent Study Library study, Lab write up, CA preparation, exam revision 4.00 Every Week 4.00
Total Weekly Learner Workload 9.00
Total Weekly Contact Hours 5.00
This course has no Part Time workload.
Resources
Recommended Book Resources
  • Rang, Dale, Ritter & Moore 2011, Rang and Dales Pharmacology, 7th Ed., Churchill Livingstone, Elsevier
  • Golan DE, Tashjian AH, Armstrong EG, Armstrong AW 2012, Principles of Pharmacology, 3rd Ed., Lippincott, Williams and Wilkins USA
  • Guyton & Hall 2010, A Textbook of Medical Physiology, 12th Ed., Elsevier, Saunders USA
This module does not have any article/paper resources
Other Resources

Module Delivered in

Programme Code Programme Semester Delivery
DK_SPHAR_7 Bachelor of Science in Pharmaceutical Science 6 Mandatory