Full Title:Pharmaceutical Chemistry
Module Code:CHEM S7012
 
Credits: 7.5
Valid From:Semester 1 - 2013/14 ( September 2013 )
Module Delivered in 2 programme(s)
Module Description:• To increase the students knowledge of organic chemistry and apply this knowledge to more advanced organic chemistry, biochemical and biological courses. • To introduce the student to a wide diversity of natural product chemicals which influence pharmaceutical chemistry.
Learning Outcomes:
On successful completion of this module the learner should be able to
  1. Identify a greater range of organic functional groups including aromatic and heterocyclic compounds.
  2. Discuss biologically relevant organic structures including carbohydrates and proteins.
  3. Assimilate the diversity of natural products and their use as pharmaceutical sources.
  4. Analyse relevant data from provided IR and NMR spectra.
  5. Practice safe organic chemistry laboratory skills for routine procedures and pharmaceutical synthesis.
  6. Examine results from scientific practicals and discuss their importance in practical reports.
 

Module Content & Assessment

Indicative Content
Nitrogen Compounds: aliphatic and aromatic
Classification and nomenclature of amines (aliphatic and aromatic) and amides. Properties, synthesis and reactions of primary, secondary, tertiary amines and aniline. Basicity of amines and comparison of basicity with amides. Sulfanilamide and sulfa drugs.
Benzene and the aromatics
Benzene: structure, resonance. Nomenclature of substituted benzene. Conditions for aromaticity including Huckels rule. Synthesis and reactions of other aromatics including phenol, toluene, benzaldehyde and benzoic acid.
Heterocyclic compounds
Introduction, nomenclature and structure of common heterocyclic structures. Pharmaceutical uses and synthesis of non-aromatic heterocyclics including pyrrolidine, piperidine and tetrahydrofuran. Conditions for maintaining aromaticity in aromatic heterocyclics. Pharmaceutical uses and synthesis of aromatic heterocyclics including pyrrole, furan, thiophene and pyridine.
Stereochemistry
Stereochemistry of simple organic molecules, recognising a chiral molecule, R and S nomenclature, the impact of sterochemistry on pharmaceutical products.
Carbohydrates
Introduction, nomenclature and structure of straight chained saccharides, monosaccharides, disaccharides, oligosaccharides and polysaccharides. Stereochemistry in carbohydrates. Use of Fischer Projections, Haworth structures and Chair structures for drawing carbohydrates. Carbohydrate derived antibiotics.
Amino-Acids and Proteins
Nomenclature, classification, general properties and stereochemistry of Amino-Acids. General nature, structure classification of proteins using pharmaceutical examples. Proteins/enzymes biological catalyst use and action.
Pharmaceutical products from natural sources
Alkaloids, Vitamins, Steroids, Terpenes,and Nucleic acids: Structures, classifications, nomenclature, medical applications and the physiological effects on humans from these naturally occurring compounds.
Nuclear magnetic resonance spectroscopy
Introduction to 1H NMR and 13C NMR. Chemical shift, integration, spin-spin splitting, interpretation of spectra.
Practical
A range of synthetic preparations, natural product isolation and medication analysis will be undertaken to give experience of organic synthetic techniques and pharmaceutical analysis. Qualitative organic analysis, identification of simple compounds by physical and chemical tests. Extraction and purification of organic materials from natural sources. In the above preparations where appropriate the students will use chromatographic and/or spectroscopic methods, to check purity and identity of the products.
Assessment Breakdown%
Course Work50.00%
End of Module Formal Examination50.00%

Full Time

Course Work
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Practical/Skills Evaluation A 3-hour weekly practical session will provide the student with the opportunity to back up the theory covered in formal lectures and discussed in tutorials with practical experience. A range of exercises will be set. Each week, students will indicate whether they have successfully completed an exercise and comment appropriately 4,5,6 30.00 0 0 Every Week 0
Continuous Assessment A detailed open-book assignment is set for 10% and then an in-class exam is set to examine this assignment for a further 10% 1,2,3 20.00 0 0 Week 10 0
No Project
No Practical
End of Module Formal Examination
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Formal Exam End-of-Semester Final Examination 1,2,3 50.00 0 0 End-of-Semester 0
Reassessment Requirement
A repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.

DKIT reserves the right to alter the nature and timings of assessment

 

Module Workload & Resources

Workload: Full Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture No Description 2.00 Every Week 2.00
Practical No Description 3.00 Every Week 3.00
Tutorial No Description 1.00 Every Week 1.00
Directed Reading No Description 3.00 Every Week 3.00
Independent Study No Description 3.00 Every Week 3.00
Total Weekly Learner Workload 12.00
Total Weekly Contact Hours 6.00
This course has no Part Time workload.
Resources
Recommended Book Resources
  • Klein, D, Organic Chemistry, 1st Ed., Wiley [ISBN: 9780471756149]
  • Hart, Craine, Hart 2007, Organic Chemistry - A short course, 12th Ed., Houghton Mifflin [ISBN: 0618215360]
  • Atkins, R.C., CareyF.A. 2007, Organic Chemistry a brief course, 3rd Ed., Mc Graw Hill [ISBN: 9780071266208]
  • Stoker, S 2007, General Organic and Biological Chemistry, 4th Ed., Houghton Mifflin [ISBN: 9780618606061]
  • Bettelheim Brown March 2004, Introduction to General Organic and Biochemistry, International Student Edition 7th Ed., Thomson/Brooks/Cole [ISBN: 0534402119]
Supplementary Book Resources
  • Quin, Tyrell 2010, Fundamentals of Heterocyclic chemistry: Importance in nature and in the synthesis of pharmaceuticals, Electronic book Ed., Wiley [ISBN: 9780470566695]
  • Pozharskii, Soldatenkov, Katritzky 2011, Heterocycles in life and society, Electronic book Ed., Wiley [ISBN: 9780470714102]
  • Davies, D 1992, Aromatic Heterocyclic chemistry, Oxford University Press [ISBN: 0198556608]
  • Balcii, M, Basic 1H and 13C NMR Spectroscopy, Electronic book Ed., Elsevier [ISBN: 9780444518118]
This module does not have any article/paper resources
Other Resources

Module Delivered in

Programme Code Programme Semester Delivery
DK_SPHAR_7 Bachelor of Science in Pharmaceutical Science 4 Mandatory
Dk_SPHAR_6 Higher Certificate in Science 4 Mandatory