Full Title:Pharmaceutical Drug Design
Module Code:PHAR S7023
 
Credits: 7.5
Valid From:Semester 1 - 2013/14 ( September 2013 )
Module Delivered in 1 programme(s)
Module Description:•To introduce the student to how the pharmaceutical industry designs medically active drug products, including both historical and current methods for pharmaceutical drug design. •To Introduce the student to a wide range of organic natural compounds especially ones, which have relevance in the pharmaceutical sector and to highlight to the student where these organic compounds can be found naturally. •To explain to the student some of the effects which these compounds have on biological metabolic systems.
Learning Outcomes:
On successful completion of this module the learner should be able to
  1. Recognise the process used for designing a new active pharmaceutical ingredient (API).
  2. Discuss a range of naturally occuring products, their sources and uses or effects.
  3. Compare the organic structures of selected pharmaceutical drugs and the impact structural change has on drug efficacy.
  4. Practice a range of organic and analytical skills for multi-step synthesis of pharmaceutical and natural products.
  5. Apply current analytical skills during laboratory practicals to analyse synthesised phamaceutical compounds.
  6. Examine results from scientific practicals and discuss the importance in journal type reports.
 

Module Content & Assessment

Indicative Content
The evolution of drug discovery
Historical introduction, the first synthetic and chemotherapy drugs, nature as a drug source, from casual observations to systematic searches. Prodrugs.
Structure-activity relationship (SAR)
Introduction to SAR, changing the organic structure (size and shape of the compound, new substituent), Case study (a SAR investigation), Quantitative structure-activity relationship (QSAR).
Terpenes and Carotenoids
Isoprene rule, identifying isoprene units and classification (class and sub-class) of terpenes (including relevant examples). Carotenoids: structure, isoprene units, irregular terpene (including relevant examples).
Steroids
Introduction, stereochemistry of the steroids, cholesterol and heart disease, steroid hormones (including, progesterone, testosterone, oestrogen, cortisol and cortisone). Vitamin D group. Medicinally useful steroids.
Alkaloids and azoles
Introduction, classification, pharmaceutically relevant alkaloids: their structure, specific class and use. Pharmaceutically relevant azoles: their structure, classification and use.
DNA based chemotherapy drugs
Purine and pyrimidine bases, nucleic acids and DNA structure. Anti-cancer drugs: types of binding/interaction with DNA structure, effect of drug on DNA structure and relevant examples. Other relevant pharmaceutical drugs based on either the DNA bases or nucleic acids.
Practical
The students will work through multi-step synthesis of pharmaceutical and natural products over the course of the practicals using a variety of organic and analytical chemistry skills. In the above preparations where appropriate the students will use chromatographic and/or spectroscopic methods to check purity and identity of the products. At the end of the muti-step synthesis the students will indicate whether they have successfully completed the exercise and comment using appropriate reports (e.g. journal type or Mahara based report)
Assessment Breakdown%
Course Work10.00%
Practical40.00%
End of Module Formal Examination50.00%

Full Time

Course Work
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Continuous Assessment In class test 1,2,3 10.00 0 0 Week 8 0
No Project
Practical
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Practical/Skills Evaluation A 3-hour weekly practical session will provide the student with the opportunity to back up the theory covered in formal lectures and discussed in tutorials with practical experience. The students will work through multi-step synthesis of pharmaceutical and natural products over the course of the practicals using a variety of organic and analytical chemistry skills. The students will indicate whether they have successfully completed an exercise and comment appropriately using appropriate reports 4,5,6 40.00 0 0 n/a 0
End of Module Formal Examination
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Formal Exam End-of-Semester Final Examination 1,2,3 50.00 0 0 End-of-Semester 0
Reassessment Requirement
A repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.

DKIT reserves the right to alter the nature and timings of assessment

 

Module Workload & Resources

Workload: Full Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture No Description 2.00 Every Week 2.00
Practical No Description 3.00 Every Week 3.00
Tutorial No Description 1.00 Every Week 1.00
Directed Reading No Description 3.00 Every Week 3.00
Independent Study No Description 3.00 Every Week 3.00
Total Weekly Learner Workload 12.00
Total Weekly Contact Hours 6.00
This course has no Part Time workload.
Resources
Recommended Book Resources
  • Bruice, P 2011, Organic Chemistry, 6th Ed., Pearson [ISBN: 9780321697684]
  • Wermuth, C 2008, The practice of medicinal chemistry, 3rd Ed., Academic Press [ISBN: 9780123741943]
  • Lednicer, D 2010, Steroid chemistry at a glance, Electronic Ed., Wiley [ISBN: 9780470660850]
Supplementary Book Resources
  • Graham, P 2001, Instant notes in medicinal chemistry, Oxford University Press [ISBN: 1859962076]
  • Aniszewski, T 2007, Alkaloids- secrets of life, Electronic Ed., Elsevier [ISBN: 9780444527363]
  • Dewick, P 2009, Medicinal Natural Products- A biosynthetic approach, 3rd Ed., Wiley [ISBN: 9780470741689]
  • Watson, D 2005, Pharmaceutical Analysis, 2nd Ed., Churchill Livingstone [ISBN: 044074453]
This module does not have any article/paper resources
Other Resources

Module Delivered in

Programme Code Programme Semester Delivery
DK_SPHAR_7 Bachelor of Science in Pharmaceutical Science 6 Elective