Full Title:Pharmaceutical Microbiology
Module Code:PHAR S7021
Credits: 7.5
Valid From:Semester 1 - 2013/14 ( September 2013 )
Module Delivered in 2 programme(s)
Module Description:This practical focused module aims to equip students with the necessary skills to carry out basic analytical microbiological procedures in accordance with European pharmacopoeia practices. It introduces students to concepts of microbial growth and control, basic infection and disease and sterile manufacture in the pharmaceutical industry.
Learning Outcomes:
On successful completion of this module the learner should be able to
  1. Summarise environmental factors that influence microbial growth.
  2. Outline the role of microbes in infection development and transmission.
  3. Discuss chemotherapeutics as microbial infection control agents.
  4. Outline the principles of pharmaceutical product contamination and preservation.
  5. Describe microbial control strategies as they are maintained and measured in the pharmaceutical industry.
  6. Analyse pharmaceutical products and the pharmaceutical manufacturing environment qualitatively and quantitatively in accordance with European pharmacopoeia guidelines.

Module Content & Assessment

Indicative Content
Topic 1: Microbial Growth
Growth media and methods, bacterial growth cycle, environmental factors influencing microbial growth, enumeration of microbial growth via plate count and membrane filtration methods.
Topic 2: Infection and Immunity
Human microbiota, overview of factors in the development of infection subsequent disease development and transmission of microbes, immune response to infection.
Topic 3: Chemotherapeutics
Selection and use of antibiotics, mode of action of antibiotics, major groups of antibiotics, antibiotic resistance development, antibiotic stewardship.
Topic 4: Product Contamination and Sterility Assurance
Pharmaceutical product contamination with emphasis on E.coli, Salmonella, Pseudomonas, and Staphylococci species. Sterile products, overview of sterilisation processes, bioburden and sterility assurance.
Topic 5: Microbial Growth Control
Overview of physical, chemical and mechanical control strategies. Focus on biocides as antiseptics, disinfectants and preservatives. Measurement of antibacterial activity.
Microbiology Practicals
1. Media preparation, inoculation and aseptic techniques 2. Culture techniques and characterisation 3. Selective and differential media 4. Preliminary identification and rapid identification procedures. 5. Microbial enumeration via total viable aerobic count and membrane filtration. 6. Evaluation of biocides via suspension tests, use dilution tests, disc diffusion test and phenol coefficient tests. 7. Preparation of pharmaceutical products for microbiological analysis. 8. Detection and quantification of E.coli, Salmonella, Pseudomonas aeruginosa and Staphylococcus aureus in pharmaceutical products. 8. Microbiological assay of antibiotics
Teaching and Learning Strategy
Lectures: Blended and flexible learning will be used throughout. This will take the form of face to face interactive lecture sessions complemented by online resources (reusable learning objects and the National Digital Learning Repository) and online interactive activities (learn smart study assignments). Students will be directed to relevant sections of appropriate text to reinforce material covered in lectures. Online demonstrations will illustrate key concepts of the course and will be available to students via the VLE throughout the year. Practical exercises are designed to enable students to develop the required technical competencies, attitudes and behaviours in microbiology.
Assessment Breakdown%
Course Work50.00%
End of Module Formal Examination50.00%

Full Time

Course Work
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Class Test The class exam will consist of a series of multiple choice, true and false, fill in the blank, short answer questions and diagram labelling. 1,2 10.00 0 0 Week 5 0
Open-book Examination Students will be provided with laboratory test results typically encountered in the pharmaceutical industry and asked to record the results observed, interpret the data and answer questions. 6 15.00 0 0 Week 12 0
Practical/Skills Evaluation Students will complete result report sheets during the practical class that are specifically designed to develop observation skills and to promote accurate data recording and subsequent interpretation in-line with pharmaceutical practices. Practical skills and competencies will be assessed via performance evaluation in class. Completion of interactive virtual labs will reinforce key concepts. 1,3,4,5,6 25.00 0 0 Every Week 0
No Project
No Practical
End of Module Formal Examination
Assessment Type Assessment Description Outcome addressed % of total Marks Out Of Pass Marks Assessment Date Duration
Formal Exam End-of-Semester Final Examination 1,2,3,5 50.00 0 0 End-of-Semester 0
Reassessment Requirement
The assessment of this module is inextricably linked to the delivery. Therefore reassessment on this module will require the student to reattend (i.e. retake) the module in its entirety.

DKIT reserves the right to alter the nature and timings of assessment


Module Workload & Resources

Workload: Full Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture No Description 3.00 Every Week 3.00
Practical No Description 3.00 Every Week 3.00
Directed Reading No Description 2.00 Every Week 2.00
Independent Study No Description 3.00 Every Week 3.00
Total Weekly Learner Workload 11.00
Total Weekly Contact Hours 6.00
This course has no Part Time workload.
Recommended Book Resources
  • Hanlon, G., Hodges, N. 2013, Essential Microbiology for Pharmaceutical Science, 1st Ed., Wiley-Blackwell [ISBN: 978-0470665343]
  • Denyer, S.P., Hodges, N., Gorman, S.P. Gilmore, B.F. 2011, Hugo and Russell's Pharmaceutical Microbiology, 8th Ed., Wiley-Blackwell [ISBN: 978-1444330632]
  • Sherlock Orla 2013, Pharmaceutical Microbiology Laboratory Manual, DkIT.
Supplementary Book Resources
  • 2013, European Pharmacopoeia, 8th Ed., Council of Europe Publishing
  • Talaro, K. P. 2011, Foundations in Micobiology: Basic Principles, 8th Ed., McGraw-Hill [ISBN: 978-0071316736]
  • Bauman 2012, Microbiology with Diseases by Taxonomy, 3rd Ed., Pearson [ISBN: 978-0321667663]
This module does not have any article/paper resources
Other Resources

Module Delivered in

Programme Code Programme Semester Delivery
DK_SPHAR_7 Bachelor of Science in Pharmaceutical Science 3 Mandatory
Dk_SPHAR_6 Higher Certificate in Science 3 Mandatory