Module Details
Module Code: |
PHAR S8Z01 |
Full Title:
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Pharmaceutical and Biopharmaceutical Science
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Valid From:: |
Semester 1 - 2018/19 ( September 2018 ) |
Language of Instruction: | English |
Module Description: |
This module will introduce the student to a range of topics in pharmaceutical and biopharmaceutical science. Pharmaceutical science encompasses a broad range of scientific disciplines that are critical to the discovery, development and manufacture of drugs and therapies.
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Module Learning Outcome |
On successful completion of this module the learner will be able to: |
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Module Learning Outcome Description |
MLO1 |
Identify a wide range of organic functional groups including natural products, aromatic and heterocyclic compounds and their use as pharmaceutical sources |
MLO2 |
Practice safe organic chemistry laboratory skills for routine procedures and pharmaceutical synthesis |
MLO3 |
Examine results from scientific practical's and discuss their importance in practical reports |
MLO4 |
Identify and describe pharmaceutical product types, current pharmaceutical legislative requirements and regulatory authorities. |
MLO5 |
Discuss the lifecycle of a range of pharmaceutical drugs from discovery to marketing and describe how cGMP guidelines apply to the stages of the lifecycle. |
MLO6 |
Evaluate the discovery, development, production and mode of action of key protein based therapeutics. |
Pre-requisite learning |
Module Recommendations
This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named DkIT module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
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No recommendations listed |
Module Indicative Content |
Pharmaceutical Industry
This element of the module will introduce the student to the pharmaceutical industry. • Pharmaceutical legislation and regulatory authorities, FDA, MHRA, HPRA, and EMA. • GMP and the industry• Lifecycle of pharmaceutical drug products from discovery to marketing.
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Pharmaceutical Chemistry
The evolution of drug discovery including synthetic drugs, chemotherapy drugs and pro-drugs. Nitrogen chemistry including aliphatic and aromatic compounds, sulphanilamide and sulfa drugs. Natural products including alkaloids, terpenes and steroids. Stereochemistry including the classification of chiral molecules and the impact of stereochemistry on pharmaceutical products.
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Biopharmaceutical Science
Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. This element of the module will introduce the process of leveraging a series of discoveries about biological macromolecules, including identification of their structures and elucidating their physiological roles, to permit their application as therapeutic agents.
• Transforming Proteins and Genes into Drugs (application of biotechnology, biochemistry, molecular biology in drug discovery).
• Therapeutic and Clinical Applications of Biopharmaceuticals: Antibodies and Derivatives; Hormones; Cytokines and Interferons. Example Case studies - Interleukins as Immunotherapeutics, - Interferon Biology and Cancer Therapy.
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Practical
A range of synthetic preparations, natural product isolation and medication analysis will be undertaken to give experience of organic synthetic techniques and pharmaceutical analysis. Qualitative organic analysis, identification of simple compounds by physical and chemical tests. Extraction and purification of organic materials from natural sources. In the above preparations where applicable the students will use chromatographic and/or spectroscopic methods to check purity and identity of the products.
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Module Assessment
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Assessment Breakdown | % |
Course Work | 10.00% |
Project | 60.00% |
Practical | 30.00% |
Module Special Regulation |
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AssessmentsFull Time On Campus
Reassessment Requirement |
A repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.
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DKIT reserves the right to alter the nature and timings of assessment
Module Workload
Workload: Full Time On Campus |
Workload Type |
Contact Type |
Workload Description |
Frequency |
Average Weekly Learner Workload |
Hours |
Lecture |
Contact |
Two hours per week of face-to-face contact with lecturer. |
Every Week |
2.00 |
2 |
Practical |
Contact |
A programme of weekly 3-hour laboratory practical sessions will run concurrently with lectures. |
Every Week |
3.00 |
3 |
Directed Reading |
Non Contact |
Lecture notes, Peer-reviewed papers, Textbooks, e-Resources |
Every Week |
3.00 |
3 |
Independent Study |
Non Contact |
Independent/Group study |
Every Week |
3.00 |
3 |
Lecturer Supervised Learning |
Contact |
Guest lecturers with expertise in both traditional pharmaceutical and biopharmaceutical science will be invited to provide an overview and insight into specifics topics of relevance. |
Every Week |
1.00 |
1 |
Total Weekly Learner Workload |
12.00 |
Total Weekly Contact Hours |
6.00 |
This module has no Part Time On Campus workload. |
Module Resources
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Recommended Book Resources |
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Klein, D. (2012), Organic chemistry, 1st. Wiley, [ISBN: 9780471756149].
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Hart, Craine, Hart. (2007), Organic chemistry - A short course, 12th. Houghton Mifflin, [ISBN: 0618215360].
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Gary Walsh.. (2007), Pharmaceutical biotechnology : concepts and applications / Gary Walsh., Hoboken, N.J. : Chichester : Wiley ; John Wiley [distributor].
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Gary Walsh. (2003), Biopharmaceuticals : biochemistry and biotechnology, Chichester : Wiley.
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Rodney Ho J.Y.. (2003), Biotechnology and biopharmaceuticals : transforming proteins and genes into drugs, New Jersey : John Wiley & Sons.
| Supplementary Book Resources |
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Bruice, P. Organic Chemistry, 6th. Pearson, [ISBN: 9780321697684].
| This module does not have any article/paper resources |
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Other Resources |
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Website, Dr Chiara Hanlon. Lecture notes and further resources, DkIT Moodle.
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Website, Virtual textbook of Organic Chemistry,
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Website, Database for IR information. Spectral Database for Organic Compounds
(SDBS),
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website, Food & Drug Administration (FDA),
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website, European Medicines Agency (EMA),
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website, Health Products Regulatory authority
(HPRA),
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website, European Directorate for the Quality of
Medicines and Healthcare',
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website, International Conference on
Harmonisation (ICH),
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website, Eudralex - EU legislation,
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