Module Details

Module Code: CHEM S7012
Full Title: Pharmaceutical Chemistry
Valid From:: Semester 1 - 2018/19 ( September 2018 )
Language of Instruction:English
Duration: 1 Semester
Credits:: 7.5
Module Owner::  
Departments: Unknown
Module Description: • To expand on the range of organic functional groups and increase the students knowledge of organic chemistry including more detailed organic synthetic reaction pathways and mechanisms. • To introduce the student to the importance of stereoisomerism and the impact on chiral pharmaceutical drugs. •To introduce the student to a wide diversity of natural product chemicals which influence pharmaceutical chemistry.
 
Module Learning Outcome
On successful completion of this module the learner will be able to:
# Module Learning Outcome Description
MLO1 Identify a greater range of organic functional groups including aromatic, heterocyclic and stereochemical compounds.
MLO2 Discuss a variety of organic synthetic reaction pathways and mechanisms.
MLO3 Analyse relevant data from provided Nuclear Magnetic Resonance (NMR) spectra.
MLO4 Assimilate the diversity of natural products and their use as pharmaceutical sources.
MLO5 Practice safe organic chemistry laboratory skills for routine procedures and pharmaceutical synthesis.
MLO6 Examine results from scientific practicals and discuss their importance in practical reports.
Pre-requisite learning
Module Recommendations
This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named DkIT module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
No recommendations listed
 
Module Indicative Content
Nitrogen Compounds: aliphatic and aromatic
Classification and nomenclature of amines (aliphatic and aromatic) and amides. Properties, synthesis and reactions of primary, secondary, tertiary amines and aniline. Basicity of amines and comparison of basicity with amides. Sulphanilamide and sulfa drugs.
Heterocyclic compounds
Introduction, nomenclature and structure of common heterocyclic structures. Pharmaceutical uses and synthesis of non-aromatic heterocyclics including pyrrolidine, piperidine and tetrahydrofuran. Conditions for maintaining aromaticity in aromatic heterocyclics. Pharmaceutical uses and synthesis of aromatic heterocyclics including pyrrole, furan, thiophene and pyridine.
Benzene and aromatic chemistry
Benzene: structure, resonance. Nomenclature of substituted benzene. Conditions for aromaticity including Huckels rule. Electrophilic aromatic substitution (EAS) reactions (including halogenation, sulphonation, nitration, Friedel Crafts alkylation and acylation). Substituted benzene reactions, activating and deactivating groups.
Stereochemistry
Stereochemistry of simple organic molecules, recognising a chiral molecule, R and S nomenclature. Optical activity, enantiomeric excess, diastereoisomers. The impact of stereochemistry on pharmaceutical products. Separation of racemic mixtures and Chiral synthesis.
Carbonyl Compound Reactivity
Alpha-carbon chemistry; formation of enols (keto-enol tautomers) and enolate ions. Alpha- substitution reactions. Aldol reaction and mixed aldol reaction. Claisen condensation and intramolecular Claisen condensation (Dieckmann cyclisation). Michael addition reaction (beta-carbon chemistry).
Nuclear magnetic resonance spectroscopy
Introduction to 1H NMR and 13C NMR. Chemical shift, integration, spin-spin splitting, interpretation of spectra.
Pharmaceutical products from natural sources
Alkaloids, Vitamins, Steroids, Terpenes,and Nucleic acids: Structures, classifications, nomenclature, medical applications and the physiological effects on humans from these naturally occurring compounds.
Practical
A range of synthetic preparations, natural product isolation and medication analysis will be undertaken to give experience of organic synthetic techniques and pharmaceutical analysis. Qualitative organic analysis, identification of simple compounds by physical and chemical tests. Extraction and purification of organic materials from natural sources. In the above preparations where appropriate the students will use chromatographic and/or spectroscopic methods, to check purity and identity of the products.
Module Assessment
Assessment Breakdown%
Course Work10.00%
Practical30.00%
Final Examination60.00%
Module Special Regulation
 

Assessments

Full Time On Campus

Course Work
Assessment Type Continuous Assessment % of Total Mark 10
Marks Out Of 0 Pass Mark 0
Timing S1 Week 8 Learning Outcome 1,2
Duration in minutes 0
Assessment Description
A detailed open-book assignment is set to examine the students ability to independently research the required questions set. The student must research the answer in both supplied lecture notes and outside references (books, websites etc.)
No Project
Practical
Assessment Type Practical/Skills Evaluation % of Total Mark 30
Marks Out Of 0 Pass Mark 0
Timing Every Week Learning Outcome 5,6
Duration in minutes 0
Assessment Description
A 3-hour weekly practical session will provide the student with the opportunity to back up the theory covered in formal lectures and discussed in tutorials with practical experience. A range of exercises will be set. Each week, students will indicate whether they have successfully completed an exercise and comment appropriately
Final Examination
Assessment Type Formal Exam % of Total Mark 60
Marks Out Of 0 Pass Mark 0
Timing End-of-Semester Learning Outcome 1,2,3,4
Duration in minutes 0
Assessment Description
End-of-Semester Final Examination
Reassessment Requirement
A repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.

DKIT reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time On Campus
Workload Type Contact Type Workload Description Frequency Average Weekly Learner Workload Hours
Lecture Contact No Description Every Week 3.00 3
Practical Contact No Description Every Week 3.00 3
Directed Reading Non Contact No Description Every Week 3.00 3
Independent Study Non Contact No Description Every Week 3.00 3
Total Weekly Learner Workload 12.00
Total Weekly Contact Hours 6.00
This module has no Part Time On Campus workload.
 
Module Resources
Recommended Book Resources
  • Klein, D. Organic Chemistry, 1st. Wiley, [ISBN: 9780471756149].
  • Bruice, P. Organic Chemistry, 7th. Pearson, [ISBN: 9780321697684].
  • Hart, Craine, Hart. (2007), Organic Chemistry - A short course, 12th. Houghton Mifflin, [ISBN: 0618215360].
  • Atkins, R.C., CareyF.A.. (2007), Organic Chemistry a brief course, 3rd. Mc Graw Hill, [ISBN: 9780071266208].
Supplementary Book Resources
  • Quin, Tyrell. (2010), Fundamentals of Heterocyclic chemistry: Importance in nature and in the synthesis of pharmaceuticals, Electronic book. Wiley, [ISBN: 9780470566695].
  • Balcii, M. Basic 1H and 13C NMR Spectroscopy, Electronic book. Elsevier, [ISBN: 9780444518118].
  • Palleros, D.R. Experimental Organic Chemistry, 1st. Wiley, [ISBN: 0471282502].
This module does not have any article/paper resources
Other Resources