Module Details
Module Code: |
PHAR S7021 |
Full Title:
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Pharmaceutical Microbiology
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Valid From:: |
Semester 1 - 2018/19 ( September 2018 ) |
Language of Instruction: | |
Module Owner:: |
Orla Sherlock
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Module Description: |
This practical focused module aims to equip students with the necessary skills to carry out basic analytical microbiological procedures in accordance with European pharmacopoeia practices. It introduces students to concepts of microbial growth and control, basic infection and disease and sterile manufacture in the pharmaceutical industry.
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Module Learning Outcome |
On successful completion of this module the learner will be able to: |
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Module Learning Outcome Description |
MLO1 |
Summarise environmental factors that influence microbial growth. |
MLO2 |
Outline the role of microbes in infection development and transmission. |
MLO3 |
Discuss chemotherapeutics as microbial infection control agents. |
MLO4 |
Outline the principles of pharmaceutical product contamination and preservation. |
MLO5 |
Describe microbial control strategies as they are maintained and measured in the pharmaceutical industry. |
MLO6 |
Analyse pharmaceutical products and the pharmaceutical manufacturing environment qualitatively and quantitatively in accordance with European pharmacopoeia guidelines. |
Pre-requisite learning |
Module Recommendations
This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named DkIT module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
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No recommendations listed |
Module Indicative Content |
Topic 1: Microbial Growth
Growth media and methods, bacterial growth cycle, environmental factors influencing microbial growth, enumeration of microbial growth via plate count and membrane filtration methods.
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Topic 2: Infection and Immunity
Human microbiota, overview of factors in the development of infection subsequent disease development and transmission of microbes, immune response to infection.
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Topic 3: Chemotherapeutics
Selection and use of antibiotics, mode of action of antibiotics, major groups of antibiotics, antibiotic resistance development, antibiotic stewardship.
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Topic 4: Product Contamination and Sterility Assurance
Pharmaceutical product contamination with emphasis on E.coli, Salmonella, Pseudomonas, and Staphylococci species. Sterile products, overview of sterilisation processes, bioburden and sterility assurance.
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Topic 5: Microbial Growth Control
Overview of physical, chemical and mechanical control strategies. Focus on biocides as antiseptics, disinfectants and preservatives. Measurement of antibacterial activity.
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Microbiology Practicals
1. Media preparation, inoculation and aseptic techniques
2. Culture techniques and characterisation
3. Selective and differential media
4. Preliminary identification and rapid identification procedures.
5. Microbial enumeration via total viable aerobic count and membrane filtration.
6. Evaluation of biocides via suspension tests, use dilution tests, disc diffusion test and phenol coefficient tests.
7. Preparation of pharmaceutical products for microbiological analysis.
8. Detection and quantification of E.coli, Salmonella, Pseudomonas aeruginosa and Staphylococcus aureus in pharmaceutical products.
8. Microbiological assay of antibiotics
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Teaching and Learning Strategy
Lectures: Blended and flexible learning will be used throughout. This will take the form of face to face interactive lecture sessions complemented by online resources (reusable learning objects and the National Digital Learning Repository) and online interactive activities (learn smart study assignments). Students will be directed to relevant sections of appropriate text to reinforce material covered in lectures. Online demonstrations will illustrate key concepts of the course and will be available to students via the VLE throughout the year. Practical exercises are designed to enable students to develop the required technical competencies, attitudes and behaviours in microbiology.
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Module Assessment
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Assessment Breakdown | % |
Course Work | 25.00% |
Practical | 25.00% |
Final Examination | 50.00% |
Module Special Regulation |
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AssessmentsFull Time On Campus
Reassessment Requirement |
Reattendance
The assessment of this module is inextricably linked to the delivery. Therefore reassessment on this module will require the student to reattend (i.e. retake) the module in its entirety.
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DKIT reserves the right to alter the nature and timings of assessment
Module Workload
Workload: Full Time On Campus |
Workload Type |
Contact Type |
Workload Description |
Frequency |
Average Weekly Learner Workload |
Hours |
Lecture |
Contact |
No Description |
Every Week |
3.00 |
3 |
Practical |
Contact |
No Description |
Every Week |
3.00 |
3 |
Directed Reading |
Non Contact |
No Description |
Every Week |
2.00 |
2 |
Independent Study |
Non Contact |
No Description |
Every Week |
3.00 |
3 |
Total Weekly Learner Workload |
11.00 |
Total Weekly Contact Hours |
6.00 |
This module has no Part Time On Campus workload. |
Module Resources
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Recommended Book Resources |
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Hanlon, G., Hodges, N.. (2013), Essential Microbiology for Pharmaceutical Science, 1st. Wiley-Blackwell, [ISBN: 978-0470665343].
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Denyer, S.P., Hodges, N., Gorman, S.P. Gilmore, B.F.. (2011), Hugo and Russell's Pharmaceutical Microbiology, 8th. Wiley-Blackwell, [ISBN: 978-1444330632].
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Sherlock Orla. (2019), Pharmaceutical Microbiology Laboratory Manual, DkIT..
| Supplementary Book Resources |
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(2017), European Pharmacopoeia, 9th. Council of Europe Publishing.
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Talaro, K. P.. (2018), Foundations in Micobiology: Basic Principles, 10th. McGraw-Hill, [ISBN: 978-0071316736].
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Bauman. (2014), Microbiology with Diseases by Taxonomy, 4th. Pearson, [ISBN: 9780321819314].
| This module does not have any article/paper resources |
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Other Resources |
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Website, Study guide for textbook Essential
Microbiology for Pharmaceutical Science,
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Website, www.microbiologyonline.org.uk.
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Website, SGM- Society for General Microbiology. www.sgm.ac.uk,
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Website, Health Protection Agency, UK.. www.hpa.org.uk,
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Website, European Pharmocopoeia,
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